Preheat oven to 350ºF. In a small bowl, whisk egg, milk, and Worcestershire.
In another bowl, mix breadcrumbs, Italian seasoning, garlic powder, salt, and pepper. Mince the onion.
Add ground beef, egg mixture, dry mixture, and onion to a large bowl.
Gently mix until combined.
Shape into a loaf (approx. 4x8 inches) on a rimmed baking sheet.
Mix glaze ingredients in a small bowl. Spread evenly over the top and sides of the loaf.
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